其实,最早提出挑战的是Juan Rosai大师,他在发表于2008年的一篇文章中就明确提出:

This being the case, why call them cancer and subject the patient to the overtreatment and mental anguish that such a diagnosis may elicit? As Julian Huxley wisely stated in a lecture given at Sloan-Kettering Institute in the 1950s, “Cancer (malignancy) must be defined operatively in terms of what the tumour cells do, not what they look like; otherwise the term ceases to have biological meaning.”............Juan Rosai..........